Association between the variation of 8q24 genes expression and prostate cancer in Chinese populations in Beijing

Abstract

Objective To explore the association between the single-nucleotide polymorphism (SNP) of 8q24(rs1016343, T, rs13252298, G and rs6983561, C)genes and prostate cancer (Pca) in Chinese population in Beijing, and to analyze the relationship between these genotypes and clinical characteristics in patients with prostate cancer. Methods Based on a case-control study, 289 patients with prostate cancer and 288 age-matched control subjects were recruited. The differences of allele and genotype frequencies of 8q24(rs1016343, rs13252298 and rs6983561) genes were analyzed between the two groups and the relationships between different genotypes and clinical features such as age, body mass index (BMI), Gleason score, prostate specific antigen (PSA) level and tumor stage were investigated. Results There was significant difference in the frequency distribution of CC genotype of SNP rs6983561 between case and control groups(OR=1.91, P=0.044). The frequency distribution of CC+ TC genotypes of SNPrs1016343 had significant differences among the PCa patients with different ages (P=0.00). The frequency distribution of CC/AC+ AA genotypes of SNP rs6983561 had significant differences among the PCa patients with different tumor stage, progressive type and BMI (P=0.046, 0.034 and 0.021). The cumulative effects test of risk alleles (rs1016343 and rs6983561) showed that the risk of PCa in patients carrying 1, 2, ≥3 risk alleles was respectively 1.332, 1.416 and 1.519 folds more than that in controls. Conclusions The risk allele C of rs6982561 may be associated with the risk of Pca, tumor stage, progressive type and BMI in people in north China, and age may be correlated with the risk of PCa in people carrying risk allele T of rs1016343. Key words: Prostate neoplasms; Polymorphism, single nucleotide; Risk assessment