Abstract
Transcription factor 7-like 2 Protein (TCF7L2) has a strong role in the pathogenesis of type 2 diabetes mellitus (T2DM). Association between rs7903146 and T2D risk reported in some of populations. Also many loci such as UBE2Z rs46522 are affecting by TCF7L2 transcription factor have been found associated with T2D. The present study aimed to evaluate association of the SNPs with risk of T2D among our population. This case-control study was conducted on 150 T2D patients and 150 healthy people (as a control group) in south western Iran. Genotyping was performed by PCR-RFLP. The frequency of genotypes showed no remarkable difference between T2DM patients and control group. The odds ratios of rs7903146 (C/T) polymorphism for CC and TC genotypes were 1.9 (95% CI, 0.85 to 4.24; P=0.12) and 0.81 (95% CI, 0.47 to 1.38; P=0.43) compared with the TT genotype, respectively. The odds ratios of rs46522 (C/T) polymorphism for TT and TC genotypes were 1.75 (95% CI, 0.86 to 3.59; P=0.13) and 1.38 (95% CI, 0.81to 2.35; P=0.24) compared with the CC genotype, respectively. Our study indicates no association of T2D in south western Iran with the rs7903146 and rs46522 variants.
Highlights
Diabetes mellitus type 2 (T2DM) is known as one of the most common metabolic diseases
The odds ratios of rs7903146 (C/T) poly¬morphism for CC and total cholesterol (TC) genotypes were 1.9 and 0.81 compared with the TT genotype, respectively
No significant difference was observed in total cholesterol (TC) between the two groups (Table 1)
Summary
Diabetes mellitus type 2 (T2DM) is known as one of the most common metabolic diseases. Health Sciences License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. African Health Sciences Vol 19 Issue 3, September, 2019. Transcription factor 7-like 2 Protein (TCF7L2) has a strong role in the pathogenesis of type 2 diabetes mellitus (T2DM). Association between rs7903146 and T2D risk reported in some of populations. Many loci such as UBE2Z rs46522 are affecting by TCF7L2 transcription factor have been found associated with T2D. Conclusion: Our study indicates no association of T2D in south western Iran with the rs7903146 and rs46522 variants. Association between the UBE2Z rs46522 and TCF7L2 rs7903146 polymorphisms with type 2 diabetes in south western Iran.
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