Abstract
Disrupted transforming growth factor- β (TGF-β) signaling is involved in the development of various types of cancer and the TGF-β receptor II (TGFBR2) is a key mediator of TGF-β growth inhibitory signals. It is reported that the G-875A polymorphism in TGFBR2 is implicated in risk of various cancers. However, results for the association between this polymorphism and cancer remain conflicting. To derive a more precise estimation, a meta-analysis of 3,808 cases and 4,489 controls from nine published case-control studies was performed. Our analysis indicated that G-875A is associated with a trend of decreased cancer risk for allele A versus(vs.) allele G [odds ratio (OR) =0.64, 95% confidence intervals (CI): 0.55-0.74], as well as for both dominant model [(A/ A+G/A) vs. G/G, OR=0.76, 95% CI: 0.64-0.90] and recessive model [A/A vs. (G/G+G/A), OR=0.74, 95% CI: 0.59-0.93). However, larger scale primary studies are required to further evaluate the interaction of TGFBR2 G-875A polymorphism and cancer risk in specific cancer subtypes.
Highlights
It has been suggested that environmental and genetic factors may affect the individual’s susceptibility to cancer (Derynck et al, 2001)
An important gene identified as cancer susceptibility one is transforming growth factor β (TGF-β), which exerts tumor-suppressive effects that cancer cells must elude for malignant evolution (Massague, 2008; Li et al, 2014)
TGF-β is a member of the transforming growth factor beta family and works as a multi-functional cytokine that plays a key role in cell proliferation, apoptosis and differentiation (Massague, 2008)
Summary
It has been suggested that environmental and genetic factors may affect the individual’s susceptibility to cancer (Derynck et al, 2001). In 2001, Seijo et al (Seijo et al, 2001)reported one polymorphic variant of TGFBR2, G-875A (rs3087465), caused a G"A transversion in the promoter region of the gene. They found this base-pair change enhanced the activity of TGFBR2 transcription in normal epithelial cells and affected the specific binding with oligonucleotide probes (Seijo et al, 2001). On the basis of the important role of TGFBR2 in the carcinogenesis, this polymorphic variant identified may be functionally associated with cancer susceptibility. Here we performed a meta-analysis of the published studies to derive a more precise estimation of the association between TGFBR2 G-875A polymorphism and the cancer risk
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