Association Between The STIP1 Polymorphism And The Response To Inhaled Steroid In Children With Asthma

Abstract

Bronchial hyperresponsiveness is usually measured by bronchial challenges using direct stimuli by methacholine or indirect stimuli by adenosine 5’-monophosphate (AMP). Airway inflammation is more closely reflected by AMP challenge test. The stress-induced-phosphoprotein 1 (STIP1) is one of the genes in steroid pathway. And polymorphisms in STIP1 are correlated with lung function after corticosteroid treatment in white subjects. We investigated whether polymorphism (rs4980524) of the STIP1 was associated with clinical phenotypes and responsiveness to inhaled steroid in Korean asthmatic children.