Association between the PSMB5 and PSMC6 genetic variations and children obesity in the Latvian population

N Paramonova,T Sjakste,I Rumba-Rozenfelde,N Sjakste,S Kupca

doi:10.7124/bc.0008c3

N Paramonova, T Sjakste + Show 3 more

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https://doi.org/10.7124/bc.0008c3

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Abstract

Association between the PSMB5 and PSMC6 genetic variations and children obesity in the Latvian population

Highlights

The ubiquitin-proteasome system (UPS) has been recently shown to be implicated in the pathogenesis of obesity (OB)
It has been demonstrated that plasma ubiquitin and proteasome levels inversely correlated with a male body mass index in Southern Taiwan and Japanese population [1, 2] and that the proteasome dysfunction mediated the obesity-induced endoplasmic reticulum stress and insulin resistance in the liver [3]
Earlier we have detected the association of the PSMA3 gene polymorphisms with susceptibility to obesity in Latvian children [6]

Summary

Introduction

The ubiquitin-proteasome system (UPS) has been recently shown to be implicated in the pathogenesis of obesity (OB). It has been demonstrated that plasma ubiquitin and proteasome levels inversely correlated with a male body mass index in Southern Taiwan and Japanese population [1, 2] and that the proteasome dysfunction mediated the obesity-induced endoplasmic reticulum stress and insulin resistance in the liver [3]. A significant association was found between genetic variants of the PSMD9 gene and obesity-associated phenotypes in Italians [4]. Earlier we have detected the association of the PSMA3 gene polymorphisms with susceptibility to obesity in Latvian children [6]. The current study was aimed to elucidate whether the single nucleotide polymorphisms (SNPs) of the PSMB5 (rs11543947) and PSMC6 (rs2295826 and rs2295827) genes are associated with the children obesity in the Latvian population

Materials and methods

Results and discussion

Conclusions