Association between the Prognosis of Stomach Adenocarcinoma (STAD) Patients and the Hotspots of Gene Copy Number Variation

Abstract

Stomach Adenocarcinoma, with complex mechanisms about progression, has the biggest proportion in Stomach Cancer, which is one of the most common causes of death in the world. It is widely acknowledged that gene mutations have relationship with Stomach Adenocarcinoma. Copy number variation (CNV), producing identical sequence in a large amount, is associated with Stomach Adenocarcinoma. There are some hotspots of gene mutations in chromosome, CNV is no exception. Their positions may potentially have association with prognosis of patients, which is poorly understood. In this research, windows with fixed length were set; the number of start and end points of CNV in the windows were calculated. The rates of Poisson Distribution in different windows were calculated and the hotspots were found. Then by using proportional hazards model, The author learned the significance of the impact of CNV in certain areas on prognosis with data from TCGA. After analyzing 180 windows, the author found 14 significant windows. These discoveries may reveal new methods of targeted therapy, promoting the precise treatment of Stomach Adenocarcinoma patients