Abstract
BackgroundKnee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Polymorphisms of IL-17A/F gene were the recognized candidate genes associated with knee osteoarthritis risk although the results were conflicting. The aim of this study was to determine whether IL-17A(rs2275913) and IL-17F(rs763780) polymorphisms confer susceptibility to knee osteoarthritis.MethodLiterature search was performed in PubMed, Medline, Cochrane Library, Web of science, Embase, and Google Scholar (last search was updated on June 20, 2019), and assessing this association was performed by calculating odds ratios with 95% confidence intervals. Statistical heterogeneity was quantitatively evaluated by using the Q statistic with its p value and I2 statistic.ResultSix case-control based studies were included involving IL-17A(rs2275913) (2134 cases and 2306 controls) and IL-17F(rs763780) (2134 cases and 2426 controls). The overall analysis suggested that the A allele of the rs2275913 polymorphism, and the C allele of the rs763780 polymorphism in the IL-17 gene may increase the risk of OA. However, subgroup analysis revealed that no association between IL-17A(rs2275913) gene and knee OA risk was found in Caucasian population.ConclusionsThis meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians. However, because of the limitations of the present study, additional larger studies are needed to confirm our findings in the future.
Highlights
Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes
This meta-analysis revealed that the IL-17A(rs2275913) gene polymorphisms may increase the risk of knee OA in Asians, and the IL-17F(rs763780) gene polymorphisms may increase the risk of knee OA both in Asians and Caucasians
The remaining 29 articles were sent for full text review, which excluded 11 articles without relevant to the association between IL-17 gene with knee OA, 6 not about rs2275913 and rs763780 polymorphism, and 6 relevant to rheumatoid arthritis (RA) instead of knee OA (Fig. 1)
Summary
Knee osteoarthritis is a joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes. Knee osteoarthritis (OA) is a common joint disease which is characterized by degeneration of articular cartilage and subsequent subchondral bone changes [1]. The incidence of knee OA is high, with an estimated 14 million symptomatic patients in the USA [2]. It is an enormous burden on the national economy and healthcare system. IL-17A is a member of IL-17 families and is a pro-inflammatory cytokine associated with many inflammatory diseases, such as rheumatoid arthritis (RA), ankylosing spondylitis, and systemic lupus erythematosus [10].
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