Abstract
Background: Currently, the incidence of gastrointestinal stromal tumors (GIST) is increasing rapidly worldwide. Malnutrition may increase the risk of perioperative complications and affect the prognosis of patients. However, previous studies on the nutritional status of GIST patients and its impact on prognosis are limited. Therefore, this study aims to explore the incidence of malnutrition in newly diagnosed GIST patients, the proportion of participants in need of nutritional intervention, and the relationship between nutritional status and overall survival (OS).Methods: We retrospectively analyzed the clinical data of GIST patients treated in our hospital from January 2014 to January 2018. Nutritional Risk Screening 2002 (NRS2002) and Patient-Generated Subjective Global Assessment (PG-SGA) were used to assess the nutritional status of all patients. This study was to investigate the clinical significance of PG-SGA by analyzing the relationship between PG-SGA score and OS.Results: A total of 1,268 newly diagnosed GIST patients were included in this study, of which 77.76% were at risk of malnutrition (NRS2002 score ≥ 3), and the incidence of malnutrition was 10.09% (PG-SGA score ≥ 4). Meanwhile, we found 2.29% of the patients required urgent nutritional support (PG-SGA score ≥ 9). Multivariate analysis showed that age (p = 0.013), BMI (p = 0.001), weight loss (p = 0.001), anemia (p = 0.005), pre-albumin (p = 0.010), albumin (p = 0.002), tumor location (p = 0.001), tumor size (p = 0.002), and NIH classification (p = 0.001) were risk factors for nutritional status. The prognosis was significantly in GIST patients with different PG-SGA score at admission (p < 0.05).Conclusion: This study suggested that malnutrition is common in newly diagnosed GIST patients, and the higher the PG-SGA score, the worse the clinical outcome.
Highlights
Gastrointestinal stromal tumors (GIST) is the most common mesenchymal tumor in the gastrointestinal tract, which is often caused by the mutation of KIT and PDGFRA genes [1, 2]
A total of 1,268 newly diagnosed gastrointestinal stromal tumors (GIST) patients were included in this study, of which 77.76% were at risk of malnutrition (NRS2002 score ≥ 3), and the incidence of malnutrition was 10.09% (PG-SGA score ≥ 4)
This study suggested that malnutrition is common in newly diagnosed GIST patients, and the higher the Patient-Generated Subjective Global Assessment (PG-SGA) score, the worse the clinical outcome
Summary
Gastrointestinal stromal tumors (GIST) is the most common mesenchymal tumor in the gastrointestinal tract, which is often caused by the mutation of KIT and PDGFRA genes [1, 2]. Numerous studies have demonstrated that nutritional deficiency account for about 85% of all patients diagnosed with cancer, of whom about 50–90% have weight loss and malnutrition at the beginning of treatment [4,5,6]. Malnutrition in patients with malignant tumors can lead to low immune function, increase perioperative infection rates, prolong hospitalization time, increase medical costs, and more importantly, affect quality of life and prognosis [7,8,9]. Malnutrition may increase the risk of perioperative complications and affect the prognosis of patients. This study aims to explore the incidence of malnutrition in newly diagnosed GIST patients, the proportion of participants in need of nutritional intervention, and the relationship between nutritional status and overall survival (OS)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
