Abstract
The expected effect of androgen-deprivation therapy is one of the important criteria when choosing therapy in patients with prostate cancer. No less significant factor is the time of its implementation. The study showed that high expression of androgen receptors (AR) in the tumor tissue against the background of low estrogen receptor α (ER α ) expression is characteristic of patients in whom the effect of androgen-deprivation therapy was observed for 12 months. A set of parameters has been identified that makes it possible to predict the duration of response to androgen-deprivation therapy in patients with prostate cancer, which include the patient’s age, testosterone level, prostate specific antigen, expression level of AR, ER α . These data allow us to consider these parameters as additional informative markers, to predict not only the expected effect, but also its duration.
Highlights
Связь молекулярных маркеров с эффективностью и временем ответа на андрогендепривационную терапию у больных раком предстательной железы
The study showed that high expression of androgen receptors (AR) in the tumor tissue against the background of low estrogen receptor α (ERα) expression is characteristic of patients in whom the effect of androgen-deprivation therapy was observed for 12 months
A set of parameters has been identified that makes it possible to predict the duration of response to androgen-deprivation therapy in patients with prostate cancer, which include the patient’s age, testosterone level, prostate specific antigen, expression level of AR, ERα
Summary
NM – номер последовательности РНК в NCBI Nucleotide Database (http://www.ncbi.nlm.nih.gov / nuccore); п.н. – пары нуклеотидов; F – прямой праймер; R – обратный праймер. NM – the number of a RNA sequence in the NCBI Nucleotide Database (http://www.ncbi.nlm.nih.gov / nuccore); bs – base pairs; F – forward primer; R – reverse primer. Статистическую обработку результатов осуществляли с помощью пакета программ Statistica 8.0. Проверку предположения о нормальности распределения признаков выполняли с применением критерия Колмогорова–Смирнова. При построении статистической модели был использован дискриминантный анализ. Результаты В результате проведенного исследования отмечено, что пациенты в группах различались по возрасту, уровню тестостерона и содержанию ПСА Клинико-морфологические характеристики пациентов с раком предстательной железы в зависимости от продолжительности эффекта андрогендепривационной терапии
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
