Abstract
Spontaneous preterm delivery (SPTD) with gestational age between 28 and 37 complete weeks was reported to have a genetic predisposition in lipids metabolism. This study aimed to investigate the association between the lipid levels and gene polymorphisms of ABCA1 (rs2422493), APOE (rs7412) and HMGCR (rs12916) in Chinese pregnant women with SPTD. A case-control study was conducted at the baseline randomization in 200 SPTD and 178 healthy full term delivery (FTD) women. Maternal blood lipids were detected close to delivery of fetus in SPTD group and in FTD group with gestational age-matched. Cord blood lipids were detected after delivery in two groups. Three genotypes both in maternal and cord blood were determined by real time PCR. The results showed that the levels of total cholesterol (TCHO), triglyceride (TG), high density lipoprotein (HDL), and low-density lipoprotein cholesterol (LDL) in the maternal blood in the SPTD group were significantly lower than those in the FTD group, while the levels of TCHO, HDL, and LDL in the cord blood in the SPTD group were significantly higher than those in the FTD group. In the SPTD subjects, the levels of TG and LDL in the maternal blood were associated with different genotypes of HMGCR gene rs12916 loci. These results indicate that abnormal lipid metabolism may exist in SPTD women and the premature fetus and the HMGCR gene may be a susceptible gene for SPTD.
Highlights
Preterm delivery (PTD) is the leading cause of prenatal morbidity and mortality
There were no significant differences in age, parity and body mass index (BMI) between Spontaneous preterm delivery (SPTD) and full-term delivery (FTD) groups
Compared with FTD subjects, the levels of total cholesterol (TCHO), TG, high density lipoprotein (HDL), and low-density lipoprotein cholesterol (LDL) in the maternal blood were significantly lower while the levels of TCHO, HDL, and LDL in the cord blood were significantly higher in the SPTD subjects (Fig 1)
Summary
Preterm delivery (PTD) is the leading cause of prenatal morbidity and mortality. The incidence of PTD is approximately 7.5–12.5% worldwide [1]. The probabilities of having cardiovascular disease and other adverse consequences are higher in PTD babies than those in full-term delivery (FTD) babies [2]. Despite many efforts that have been made by researchers and doctors, the incidence of preterm birth has not been significantly decreased.
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