Abstract
BackgroundClinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF.FindingsWe evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. For this, the PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients.ConclusionsIn our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes.
Highlights
Clinical complications appear to be a decisive factor for the prognosis of patients
In our study we evaluated the association of the rs12255372 polymorphism (IVS4G > T mutation) in transcription factor 7–like gene (TCF7L2) gene with the presence of diabetes in patients with Cystic Fibrosis (CF)
This study was approved by the Ethics Committee of the Faculty of Medical Sciences of University of Campinas UNICAMP (#528/2008)
Summary
Clinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF. Findings: We evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. The PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients. Conclusions: In our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes
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