Abstract
BackgroundMany epidemiological studies have suggested that insulin-like growth factor1 (IGF1) gene single-nucleotide polymorphisms (SNPs) may be associated with cancer risk. Among several commonly studied polymorphisms in IGF1 gene, rs2195239 and rs2162679 attracted many attentions. So we perform a meta-analysis to determine potential associations between IGF1 rs2195239 and rs2162679 polymorphisms and cancer risk.MethodsWe retrieved relevant articles from the PubMed, Embase, and Web of Science databases up to April 30, 2018. Ultimately, thirteen studies were included in the present meta-analysis, which involved 12,515 cases and 19,651 controls. The odd ratios (ORs) and their 95% confidence intervals (CIs) were pooled to estimate the strength of the associations.Resultsrs2195239 reduces the overall cancer risk in homozygote model, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models. No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.ConclusionsIGF1 rs2195239 and rs2162679 were associated with overall cancer risk based on present studies.
Highlights
Many epidemiological studies have suggested that insulin-like growth factor1 (IGF1) gene singlenucleotide polymorphisms (SNPs) may be associated with cancer risk
No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models
The characteristics of the studies and the genotype frequencies for cases and controls of rs2195239 and rs2162679 are shown in Tables 1 and 2 respectively
Summary
Many epidemiological studies have suggested that insulin-like growth factor (IGF1) gene singlenucleotide polymorphisms (SNPs) may be associated with cancer risk. Among several commonly studied polymorphisms in IGF1 gene, rs2195239 and rs2162679 attracted many attentions. We perform a meta-analysis to determine potential associations between IGF1 rs2195239 and rs2162679 polymorphisms and cancer risk. Many studies have described the relationship between the IGF1 gene rs2195239 and rs2162679 polymorphisms and the risks of various cancers [14,15,16,17,18,19,20,21,22,23]. We performed the present meta-analysis to more precisely describe the relationship between the IGF1 rs2195239 and rs2162679 polymorphisms and cancer risk
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