Abstract
BackgroundBrucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (− 1082 G/A, − 819 C/T, − 592C/A) and IL-6 -174 G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. So far, the results of published literatures were controversial. Now, we perform a meta-analysis in different ethnic populations to get a more precise estimate of above polymorphisms with Brucellosis susceptibility.MethodsBoth OR and corresponding 95%CI were enrolled to make an assessment of the association strength through extracting genotyping frequency of cases and controls. The χ2-test based Q-statistic and I2 statistics were applied. If there was no evident heterogeneity, the fixed-effects model would be applied. If not, the random-effects model would be used.ResultsThe significant associations were only found in Asian population of − 819 loci under three genetic models as follows: (Allele model: OR = 0.60, 95%CI = 0.44–0.82, P = 0.001), (homozygote comparison: OR = 0.24, 95%CI = 0.09–0.62, P = 0.003), (recessive genetic model: OR = 0.22, 95%CI = 0.05–0.91, P = 0.036).ConclusionIn conclusion, IL-10 − 819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population. And IL-10 -1082 G/A, 592 loci and IL-6 -174 G/C polymorphism are not associated with Brucellosis risk.
Highlights
Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products
Significant associations were only found in Asian population of − 819 loci under three genetic models as follows: (Allele model: Odds ratio (OR) = 0.60, 95%Confidence interval (CI) = 0.44–0.82, P = 0.001) (Fig. 2), (Fig. 3), (Fig. 4)
Our meta-analysis shows that IL-10 -819 loci polymorphism contributes no risk to Caucasian population but may be associated with decreased risk in Asian population
Summary
Brucellosis is a quite normal zoonotic infection, which is caused by immediate contact with animals infected with Brucella or its products. IL-10 (− 1082 G/A, − 819 C/T, − 592C/A) and IL-6 -174 G/C polymorphisms have a great relationship with IL-10 and IL-6 production, which brings about Brucellosis pathogenesis and development. The number of Brucellosis patients is relatively small, it remains a severe problem and it is very popular locally in most areas of Asia and Africa [1, 2]. Multiple clinical manifestations can be shown by Brucellosis. What’s worse, nontypical clinical presentation brings difficulties to. IL-6 is another cytokine, involving in the process of inflammation response and regulating multiple biological processes such as metabolism, regeneration and nervous system [7]. It has been demonstrated that polymorphism can influence the expression of cytokine and play a crucial role in infectious diseases [8, 9]
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