Abstract
BackgroundNo previous meta-analysis was to report the association between the apolipoprotein B (APOB) XbaI and EcoRI polymorphisms and serum lipids in Chinese. We performed the study to investigate their potentially association.Methods and Results Studies in English and Chinese were found via a systematic search of Pubmed, Embase, CNKI and Wanfang databases. The dominant genetic model and random-effects model were used to pool data from individual studies. As a result, a total of 30 articles with 5611 subjects for XbaI and 2653 subjects for EcoRI were included in the current study. For the XbaI polymorphism, overall, subjects carrying X+ allele were significantly associated with higher TC,TG and LDL compared with X-X- genotype (Pvalue =0.0006, OR (95 %) = -0.55 (-0.86,-0.23); Pvalue = 0.0004, OR (95 %) = -0.30 (-0.47,-0.14); (Pvalue = 0.05, OR (95 %) = -0.23(-0.46,-0.00), respectively). Similar results were observed in the subgroups of Han, healthy individuals (HT), coronary heart disease (CHD), cerebral infarction (CI), and cholelithiasis. For HDL, positive association between X+ allele with Lower lipid value was found in CHD and CI subgroups. For EcoRI polymorphism, overall, the E- allele carriers were found to be obviously linked with elevated LDL and lower HDL compared with E + E+ genotype (Pvalue = 0.02,OR (95 %) = -0.27 (-0.49,-0.05); Pvalue = 0.01, OR (95 %) = 0.17 (0.03, 0.30), respectively). TC was significantly high in subjects carrying E- allele in the subgroup of hyperlipidemia. No evidence of publication bias was observed.ConclusionsThe two genetic variants of APOB may be associated with serum lipids in Chinese.
Highlights
Many epidemiological studies have reported that metabolic disorders in serum lipids are considerable risk factors for premature coronary artery disease and atherosclerosis [1]
The two genetic variants of apolipoprotein B (APOB) may be associated with serum lipids in Chinese
The included studies should be accordance with the later criteria: (i) studies evaluating the association of the APOB XbaI and EcoRI polymorphisms with lipids in Chinese, (ii) At least one of the lipid phenotypes was measured: total cholesterol (TC), triglyceride (TG), low density lipoprotein(LDL), and high density lipoprotein(HDL), (iii) Sufficient data involving genotype frequency as well as mean and standard deviation (SD) of lipids, (iv) If the article was a retrospective casecontrol study, each population was treated as a single study and genotype frequency among control populations must be tested for Hardy-Weinberg equilibrium (HWE)
Summary
Many epidemiological studies have reported that metabolic disorders in serum lipids are considerable risk factors for premature coronary artery disease and atherosclerosis [1]. Apolipoprotein B (APOB) is an important protein component in contribution to intermediate density lipoprotein, the formation of very low density lipoprotein, low density lipoprotein particle, and is related to the clearance of LDL in serum. Beside these, it mediates cellular uptake of cholesterol and is the ligand that binds to the LDL receptor [4]. Among these variants, we paid particular attention to the most investigated XbaI (rs693 ) in exon 26 and EcoRI (rs1042031) in exon 29 single nucleotide polymorphisms in the APOB gene.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
