Association between the Adiponectin Gene and Type 2 Diabetes in Yanbian Han and Korean Chinese Populations

Abstract

Objective This study was designed to analyze the possible association between single nucleotide polymorphisms (SNPs) within the promoter of adiponectin gene and type 2 diabetes in Yanbian Han and Korean Chinese populations. Methods We enrolled a total of 97 subjects from Yanbian, including 55 Han Chinese (13 healthy individuals and 42 type 2 diabetes patients) and 42 Korean Chinese ( 16 healthy individuals and 26 type 2 diabetes patients). Body mass index ( BMI) , fasting plasma glucose ( FPG) , total cholesterol ( TC ), and triglyceride (TG) were measured. PCR and sequencing were used for screening of SNPs of promoter of adiponectin gene. ANOVA and χ~2 test were used for analysis of data. Results The level of TG in type 2 diabetes group was higher than that in normal group in Yanbian Korean Chinese ( P = 0.033 ). The level of FPG, TC, and TG in type 2 diabetes group of Yanbian Korean Chinese were higher than those in type 2 diabetes in Yanbian Han Chinese (P =0. 038, P =0.037, and P =0.047, respectively). The frequency of haplotype of - 11426A - 11377C in type 2 diabetes group was less than in normal group in Yanbian Korean Chinese (P = 0.043). In Yanbian Han Chinese, BMI was relative to the genotype at locus of - 11426, and the level was lower in individuals with allele - 11426G than that with - 11426A (P = 0. 039). And the BMI level with genotype of AA at locus of - 11426 in Yanbian Han Chinese was higher than it in Yanbian Korean Chinese (P =0.006). Conclusion Three conclusions can be drawn.First, Yanbian Han and Korean Chinese had national difference in FPG, TC, and TG in type 2 diabetes group.Second, the haplotype of - 11426A - 11377C could be considered as a protective factor in the progression of type 2 diabetes in Yanbian Korean Chinese. Third, the SNP of - 11426A >G might be associated with obesity in Yanbian Han Chinese. Key words: Type 2 diabetes ; Adiponectin ; SNP ;