Abstract
ObjectiveMethicillin-resistant Staphylococcus aureus cause to a variety of hard to cure infections. MRSA isolates also, produce an arsenal of virulence factors contribute to severe infections. The aim of this study was to find out the relationship between agr locus and presence of S. aureus superantigens (SAgs).ResultsClinical isolates in two groups from two different states of Iran were collected. Antibiotic resistance patterns, agr typing, and virulence factor genes prevalence were identified and relationship between them was analyzed using SPSS software version16. Most of the samples were collected from wound 39 isolates in Group 1 and 61 isolates in Group 2. Frequency of MRSA strains was 38.1% in Group 1 and 52.1% in Group 2. Also, the most common resistance among both groups was to penicillin. agr positive isolates were detected in 132 isolates of Group 1 and 104 isolates of Group 2. In Conclusion, a significant relationship between the SAgs frequency and agr locus in both groups has been indicated. The production of superantigens in S. aureus plays an important role in the classification of agr locus, and this locus can affect differently in methicillin-resistant strains.
Highlights
Inappropriate use of antibiotics to treat S. aureus infections have led to the development of antibiotic resistant strains
The most common resistance among both groups was to penicillin. agr positive isolates were detected in 132 isolates of Group 1 and 104 isolates of
The production of superantigens in S. aureus plays an important role in the classification of agr locus, and this locus can affect differently in methicillin-resistant strains
Summary
1009 clinical samples were collected from patients in Hamedan (Group 1) and Sistan and baluchistan (Group 2). 160 isolates were collected from. Group 1, the most prevalent isolates were collected from blood 58 (36.25%). In Group 1, the most prevalent resistance was detected to penicillin (129, 80.62%) and to chloramphenicol (97 isolates, 60.62%). In Group 1, most of the MRSA samples were isolated from blood 66.66% (26 isolates) and wound 55.17% [32]. Whereas 0% (0 isolates) and 16.66% [1] of MSSA strains were detected in aspiration and sputum respectively. In Group 2, the most prevalent MRSA isolates were detected in blood 72.13% (44) and wound 46.34% [19], whereas MSSA isolates were identified in aspiration. MDR strains had the highest frequency of SAgs genes, Table 2. In Group 1 out of 160 isolates of S. aureus, 104 (65%) agr positive and 56 (35%) agr negative were detected. A significant relationship was found between phenotypic antibiotic resistance and mecA
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