Abstract
BackgroundEpidemiological studies have investigated the role of transforming growth factor-β1 (TGF-β1) in chronic allograft dysfunction (CAD) following kidney transplantation. TGFB1 gene polymorphisms (SNP rs1800470 and rs1800471) may be associated with the risk of CAD. In this meta-analysis, the relationship between these two variations and the risk of CAD was explored.Materials and MethodsMEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Embase, the Chinese CNKI and WANFANG databases were searched. Data were extracted and pooled results were estimated from odds ratios (ORs) with 95% confidential intervals (95% CIs). Quality assessments were performed, and publication bias of all eligible studies examined.ResultsEight studies with 1038 subjects were included in our analysis. According to the effects on TGF-β1 secretion, haplotypes were categorized as “HIGH”, “INTERMEDIATE” and “LOW”. The combined results showed a statistically significant difference of TGFB1 haplotypes between the CAD recipients and control subjects when “HIGH” with “INTERMEDIATE” and “LOW” (“HIGH” vs. “INTERMEDIATE” + “LOW”: OR: 3.56, 95% CIs: 2.20, 5.78, P < 0.001) were compared. No significant association was found between the TGFB1 codon 10 or codon 25 and the CAD risk in all five genetic models.ConclusionsOur meta-analysis has found the haplotype of TGFB1 codon 10/25 T/T G/G and T/C G/G genotypes, associated with increased production of TGF-β1, was linked with CAD risk following kidney transplantation. Moreover, no significant difference was found between TGFB1 codon 10 or codon 25 and the development of CAD.
Highlights
Kidney transplantation is the optimal therapy for end-stage renal disease [1]
No significant association was found between the TGFB1 codon 10 or codon 25 and the chronic allograft dysfunction (CAD) risk in all five genetic models
Our meta-analysis has found the haplotype of TGFB1 codon 10/25 T/T G/G and T/C G/G genotypes, associated with increased production of transforming growth factor-β1 (TGF-β1), was linked with CAD risk following kidney transplantation
Summary
Kidney transplantation is the optimal therapy for end-stage renal disease [1]. Short-term allograft survival has been significantly improved due to advancements in immuosuppressive agents and surgical techniques [2]. Various factors contribute to the pathogenesis of CAD, such as chronic calcineurin inhibitor (CNI), cyclosporine A (CsA) nephrotoxicity, fibrosis-related cytokines and immune-associated factors [6,7,8]. Among these factors, certain cytokines, including transforming www.impactjournals.com/oncotarget growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and cell tissue growth factors (CTGF), were considered to be closely associated with the development of fibrogenesis, contributing to the pathogenesis of CAD [5, 9, 10]. Epidemiological studies have investigated the role of transforming growth factor-β1 (TGF-β1) in chronic allograft dysfunction (CAD) following kidney transplantation. In this meta-analysis, the relationship between these two variations and the risk of CAD was explored
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