Association between telomere length and completed suicide observed in 71 suicide victims – Preliminary findings

Abstract

ObjectiveTelomere length has emerged as a cumulative marker for lifestyle, psychosocial stress, and cytotoxic environments. We aimed to examine the possible association between leukocyte telomere length (LTL) and completed suicide. MethodsThis study included 71 suicide completers and 117 healthy controls for whom LTL was determined by the ratio of the telomere repeat copy number to the single-copy gene copy number (T/S ratio). We compared the LTL between the suicide completers and the healthy controls and estimated the odds ratio (OR) for suicide for each age group, applying a generalized estimating equation (GEE). ResultsLTL was significantly shortened in the suicide completers as compared with the controls, overall subjects, or within-age categories (≤29 and 30–49 years). Furthermore, a longer LTL was associated with significantly decreased odds of completed suicide for those aged ≤29 years and 30–49 years (OR = 0.11, 95% confidence interval [CI] 0.03–0.37, p < .001 for the ≤29-year age group; OR = 0.54, 95% CI 0.34–0.84, p = .006 for the 30- to 49-year age group). ConclusionsThis study provides evidence regarding the relationship between shortened LTL and completed suicide, especially in those aged <50 years. Future research should further assess potential confounders and examine underlying mechanisms.