Abstract

BackgroundBiologic studies have suggested that tea may have neuroprotective activity. However, tea’s protective effect on cognitive function is controversial in human epidemiological studies, and no data, including the middle-aged, are available. The objective of this study was to investigate the association of habit, frequency, and types of tea consumption with incident cognitive impairment in middle-aged and older adults.MethodsData from the Asymptomatic Polyvascular Abnormalities in Community study were used (aged over 40y). We gathered information on tea consumption, including habit, frequency, and types, via a standardized questionnaire and assessed cognitive function by Mini-Mental State Examination (MMSE) and/or Montreal Cognitive Assessment (MoCA). Three thousand eight hundred sixty-eight and 806 participants were selected in MMSE and MoCA subgroups. Multivariate logistic regression models were utilized to examine associations between tea consumption and cognitive impairment in middle-aged and older participants.ResultsIn MMSE analyses, after adjustment for potential confounding factors, habitual (odds ratio (OR) 0.47, [95% confidence interval (CI) 0.33–0.68], p < 0.001) and high frequency (p trend < 0.001) of tea intake were associated with a lower risk of cognitive impairment. The risk of cognitive impairment was lower in green tea consumption (OR 0.36, [95% CI 0.22–0.61], p < 0.001) than other types (OR 0.59, [95% CI 0.38–0.91], p = 0.017). In MoCA analyses, we got similar results.ConclusionsHabitual tea consumption, especially high-frequency and green tea consumption, was significantly associated with a lower prevalence of cognitive impairment in middle-aged and older individuals.

Highlights

  • Biologic studies have suggested that tea may have neuroprotective activity

  • Participants with normal cognition detected by Mini-Mental State Examination (MMSE) were most likely to be younger and female, have a higher

  • Before adjusting for possible covariates in MMSE subgroup analyses, habitual tea intake was associated with low risks of cognitive impairment

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Summary

Introduction

Biologic studies have suggested that tea may have neuroprotective activity. tea’s protective effect on cognitive function is controversial in human epidemiological studies, and no data, including the middleaged, are available. The objective of this study was to investigate the association of habit, frequency, and types of tea consumption with incident cognitive impairment in middle-aged and older adults. The number of patients with dementia will be expected to reach 152 million in 2050 [1]. This disease brings immense burdens to the social economy and families. Due to the limitation of treatments available for dementia, the emphasis has been placed on preventing the disease by modifying risk factors [3]. Identifying risk factors for cognitive impairment in the middle-aged could help avoid and delay the development of dementia

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