Abstract
Tacrolimus (TAC) is highly effective at preventing rejection and prolonging graft function in heart transplant (HT) recipients. The nephrotoxic effect of TAC remains one of its most significant limitations. TAC induced nephrotoxicity is strongly associated with the concentration of TAC in whole blood; emerging data suggests that the rate of drug metabolism may also contribute. The ratio of TAC blood concentration to TAC dose (C/D ratio) has been shown to be a reliable marker for the rate of metabolism in renal transplant recipients, but has not been evaluated in HT patients. This study aimed to characterize the relationship between the rate of TAC metabolism and its effects on renal function in HT recipients.
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