Abstract
General health conditions of a patient may influence the healing of periapical lesions and therefore the outcome of the root canal treatment. Both systemic and tooth-based factors can have a negative impact on the success of the endodontic treatment. The aim of this literature review is to investigate the impact of systemic health factors on the outcome of endodontic treatment. A review of related literature has been conducted in order to determine which systemic diseases can negatively influence the healing of periapical lesions. The outcome of treating endodontic infections might be poorer by patients with general medical conditions such as diabetes mellitus, hypertension, renal diseases, immunosuppressive conditions, etc.
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