Association Between Steroid Use and Nephropathy in Patients Who Were Administered a Proton Pump Inhibitor: Analysis of the Japanese Adverse Event Report Database.

Abstract

This study used the Japanese Adverse Drug Event Report database to investigate whether steroid use decreases the risk of nephropathy in patients who were administered a proton pump inhibitor (PPI). Disproportionality of kidney injury was observed between patients who did and those who did not use steroids while taking lansoprazole (reporting odds ratio, 0.78; 95% confidence interval [CI], 0.65-0.93; P = .002) or rabeprazole (reporting odds ratio, 0.69; 95%CI, 0.53-0.89; P = .005). Multiple logistic regression analysis revealed a significantly negative association of kidney injury with steroid use (odds ratio [OR], 0.85; 95%CI, 0.75-0.96; P = .011) and a significantly positive association with the presence of chronic kidney disease (OR, 1.66; 95%CI, 1.44-1.90; P < .001), the presence of comorbidities that relate to nephropathy (OR, 1.43; 95%CI, 1.29-1.59; P < .001), male sex (OR, 1.25; 95%CI, 1.13-1.39; P < .001), and age ≥80 years (OR, 1.21; 95%CI, 1.07-1.37; P = .002). These findings suggest that steroid use may decrease the risk of proton pump inhibitor-induced nephropathy.