Association between Statin Use and Meniere's Disease: Results from a National Health Screening Cohort.

So Young Kim,Chanyang Min,Hyo Geun Choi,Dae Myoung Yoo

doi:10.3390/ijerph18168692

Abstract

The protective effects of statins against inner ear diseases have been suggested. This study investigated the relationship between previous statin use and the occurrence of Meniere’s disease (MD). Participants ≥40 years old in the Korean National Health Insurance Service-Health Screening Cohort 2002–2015 were enrolled. A total of 7734 MD participants were matched with 38,670 comparison participants. The dates of statin prescriptions for the 2 years before the onset of MD were examined. A conditional logistic regression analysis was performed to estimate the odds ratios (ORs) of statin use for MD. Regarding the different types of statins, lipophilic statins, but not hydrophilic statins, were associated with lower odds of MD in the <65 year-old group (adjusted OR = 0.81, 95% CI = 0.68–0.97, p = 0.023). Prior statin use did not show association with MD in the adult population. Regarding the different types of statins, lipophilic statin use was related to a lower rate of MD in a middle-aged population.

Highlights

Statins are lipid-lowering agents that inhibit HMG-CoA reductase [1]
The rates of alcohol consumption, Charlson Comorbidity Index (CCI) score, and dyslipidemia history were higher in the Meniere’s disease (MD) group than in the comparison group (p < 0.05)
The dates of statin use were associated with higher odds for MD in the crude model (OR = 1.26, 95% CI = 1.17–1.37, p < 0.001, Table 2)

Summary

Introduction

Statins are lipid-lowering agents that inhibit HMG-CoA reductase [1]. They are widely used for the treatment and prevention of dyslipidaemia and other cardiovascular disorders [2]. A number of randomized clinical trials demonstrated decreases in all-cause (risk ratio [RR] = 0.86, 95% confidence intervals [95% CI] = 0.80–0.93) and cardiovascular (RR = 0.69, 95% CI = 0.54–0.88) mortality related to statin therapy [2]. A growing number of reports have widened the indications of statin prescription for inflammatory diseases, such as asthma and chronic obstructive pulmonary disease, and neurologic disorders, such as Alzheimer’s disease and Parkinson’s disease [3]. Statins have been suggested to have anti-inflammatory and antioxidative effects as well as lipid-lowering effects [4]

Methods

Results

Conclusion