ASSOCIATION BETWEEN SPORT RELATED POLYGENIC PROFILE AND MAGNITUDE OF PHYSICAL PERFORMANCES CHANGES FOLLOWING RESISTANCE TRAINING AMONG NOVICE FIELD HOCKEY ATHLETES

Abstract

Background: Studies have shown that inter-individual variation in response to resistance training is attributed to genetic variation. Aim: To correlate total genotype scores (TGS) with the magnitude of physical performances (skeletal muscle mass, muscular strength, muscular power, performance decrement, and VO2max) change, following 8 weeks of resistance training. Methods: We included forty-five (N=45) participants (age = 16.53 ± .5 years old, body mass = 61.03 ± 6.67 kg, height = 1.67±.05 m) and randomly assigned into; high intensity resistance training (n=15), moderate intensity resistance training (n=15) and a control group (n=15). They were prescribed with the same upper and lower body exercise routines. Pre- and post-test physical performances were measured. Genotyping was conducted using in-house designed allele-specific polymerase chain reaction assays. TGS for nine SNPs: Angiotensin Converting Enzyme, ACE rs1799752; Alpha-acitin-3, ACTN3 rs1815739; Adrenergic Receptor B3, ADRB3 rs4994; Angiotensinogen, AGT rs699; Bradykinin Receptor B2, BDKRB2 rs1799722; Peroxisome Proliferator-Activated Receptor Alpha, PPARA rs4253778; Peroxisome Proliferator-Activated Receptor Gamma Co-Activator 1-Alpha, PPARGC1A rs8192678; Thyrotropin Releasing Hormone Receptor, TRHR rs7832552 and Vascular Endothelial Growth Factor, VEGF rs1870377,were calculated and assigned with strength-power and endurance quality. Pearson correlation analysis was employed to investigate the correlation between TGS, and magnitude of physical performances change following intervention. Result: There is a significant correlation between strength-power TGS with lower body muscular strength (r= .65, p<.01) and power (r= -.69, p<.01) following moderate intensity resistance training. Conclusion: In this study, it is demonstrated that participants with higher strength-power TGS, gained greater lower body strength improvement and lesser muscular power decrement even with moderate intensity as compared to high intensity resistance training. Therefore, personalising training based on athlete’s genetic profile may optimise performance.