Association between Sphingosine-1-Phosphate and Bone Characteristics in Men and Post-menopausal Women in Malaysia

Abstract

Event Abstract Back to Event Association between Sphingosine-1-Phosphate and Bone Characteristics in Men and Post-menopausal Women in Malaysia Nasrin Shahifar1, Subashini C. Thambiah1, Siti Yazmin Zahari Sham1, Salmiah Md Said2, Swan S. Yeap3, 4, Fen L. Hew3, 4 and Intan Nureslyna Samsudin1* 1 Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Malaysia 2 Department of Community Health, Faculty of Medicine and Health Sciences, Putra Malaysia University, Malaysia 3 Puchong Specialist Clinic, Malaysia 4 Subang Jaya Medical Centre, Malaysia Background Prevention of osteoporotic fracture requires identification of individuals at high risk of fracture. There remains an inadequate predictive discrimination ability of current tools to identify those at risk. Sphingosine-1-phosphate (S1P) being a novel marker of bone metabolism may complement the current model. We determined the association between plasma S1P with sociodemographic factors, clinical characteristics, bone mineral density (BMD) and blood tests for bone profile among healthy adult residents of Puchong and Kajang, Malaysia. Methods A cross-sectional study was carried out involving Chinese subjects aged 50-90 years old with no previous history of osteoporosis who attended a health screening program in Puchong Specialist Clinic. Each subject had a BMD determined by a dual-energy x-ray absorptiometry (DXA) scan. Fasting blood samples were analysed for 25-hydroxyvitamin D, parathyroid hormone (iPTH), calcium, phosphate, procollagen type 1 amino-terminal propeptide (P1NP), carboxy-terminal collagen crosslinks (CTX) and S1P. Pearson’s and Spearman’s correlation tests were used to determine the associations between S1P with sociodemographic factors and bone characteristic parameters. Results There were 45 (34.4%) males and 86 (65.6%) post-menopausal women with median age of 65 (IQR=17) years old. Osteopaenia and osteoporosis were noted in 46.6% and 29.0% of study subjects, respectively. The S1P levels in men (2.12±0.75 µmol/L) and post-menopausal women (1.96±0.68 µmol/L) were not statistically different (p=0.235). S1P had a moderate negative correlation with iPTH (r=-0.232; p=0.008) but not with the other laboratory parameters, age, body mass index and individual BMD values at various sites in both men and post-menopausal women. Conclusion Osteoporosis was diagnosed in almost 30% of subjects. S1P levels did not differ between genders. It did not correlate with either of the bone turnover markers (P1NP and CTX) nor with any BMD values at various sites. S1P levels in the subjects were however low which may suggest that the risk of future osteoporotic fracture is low. Keywords: Sphingosine-1-phosphate, Osteoporosis, osteopenia, Men, post-menopausal women Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Miscellaneous Citation: Shahifar N, Thambiah SC, Zahari Sham S, Md Said S, Yeap SS, Hew FL and Samsudin I (2019). Association between Sphingosine-1-Phosphate and Bone Characteristics in Men and Post-menopausal Women in Malaysia. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2019.63.00026 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. 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Received: 08 Nov 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Intan Nureslyna Samsudin, Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor Daruh Ehsan, Selangor, 43400, Malaysia, intanlyna@upm.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nasrin Shahifar Subashini C Thambiah Siti Yazmin Zahari Sham Salmiah Md Said Swan S Yeap Fen L Hew Intan Nureslyna Samsudin Google Nasrin Shahifar Subashini C Thambiah Siti Yazmin Zahari Sham Salmiah Md Said Swan S Yeap Fen L Hew Intan Nureslyna Samsudin Google Scholar Nasrin Shahifar Subashini C Thambiah Siti Yazmin Zahari Sham Salmiah Md Said Swan S Yeap Fen L Hew Intan Nureslyna Samsudin PubMed Nasrin Shahifar Subashini C Thambiah Siti Yazmin Zahari Sham Salmiah Md Said Swan S Yeap Fen L Hew Intan Nureslyna Samsudin Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.