Abstract
Article Association between SOX17, Wif-1 and RASSF1A promoter methylation status and response to chemotherapy in patients with metastatic gastric cancer was published on February 1, 2021 in the journal Clinical Chemistry and Laboratory Medicine (CCLM) (volume 59, issue 2).
Highlights
To the Editor, Gastric cancer is one of the most frequently diagnosed cancers worldwide [1]
Several genes are generally hypomethylated in cancer patients, whereas tumor suppressor genes are hypermethylated in the vast majority of cases [3]
Our study material consisted of 105 blood samples obtained from gastric cancer patients suffering from metastatic disease
Summary
To the Editor, Gastric cancer is one of the most frequently diagnosed cancers worldwide [1]. The relapse of the disease may be due to methylation patterns already present in the tumor before the onset of any treatment, so that specific methylation patterns cause a more aggressive phenotype with a poor response to chemotherapy [6]. Karamitrousis et al.: Gene methylation and response to chemotherapy in gastric cancer the present study, we tried to analyze the promoter methylation status of tumor-suppressor genes SOX-17, Wif-1 and RASSF1A.
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