Association between Soluble Contents CD40 Ligand (sCD40L) and Acute Coronary Syndrome (ACS)

Abstract

Background: Acute coronary syndrome (ACS) is a manifestation of coronary heart disease (CHD), which the leading cause of death in Indonesia. CD40 ligand (CD40L) stored in alpha platelet granules will be rapidly transferred to the surface when the platelets are activated and subsequently released from the surface as a soluble CD40 ligand (sCD40L). Soluble CD40 ligand (sCD40L) acts as a bridge between the inflammatory process, atherosclerosis, and thrombosis. This study aims to study the relationship between sCD40L levels and the incidence of ACS in patients with chest pain in Dr.Soetomo General Hospital, Surabaya. Method: Research subjects were 40 patients with chest pain who came to Emergency Room at Dr.Soetomo General Hospital, Surabaya. The patients were grouped based on the diagnosis of ACS and non-ACS with the electrocardiogram and troponin T. Serum levels of patients that examined by sCD40L with enaminelinked immunosorbent assay (ELISA) method from Quantikine®. Results: Twenty-six (65%) were diagnosed with ACS and 14 (35%) were non ACS. The diagnosis of ACS includes ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina (UA), with the highest proportion being STEMI at 15 (57%). Spearman correlation test of sCD40L level with ACS incidence got correlation coefficient rho (?) = 0.52 (p = 0.001). Conclusion: There was a moderate positive correlation between sCD40L levels and ACS incidence in patients with chest pain.