Association Between SLC30A8 Gene rs3802177 Polymorphism and T2DM in Asian Population-a Meta-Analysis

Abstract

To further confirm the association between SLC30A8 gene rs3802177 polymorphism and T2DM in Asian population, we collect data from multiple relevant papers and performed Meta-analysis. We constructed allele model, dominant model and recessive model by fixed effects model or random effects models which were determined according to the Q value and I2 value calculated by heterogeneity test. OR with 95%CI was selected as evaluation index to discuss the influences of SLC30A8 gene rs3802177 polymorphisms on T2DM. The most reasonable genetic model was determined by comparisons between every two genotypes. According to the inclusion and exclusion criteria, a total of five qualified articles were used for data retrieval, which include 6234 cases and 6169 controls. Significant association were found in all the genetic models (C vs T: OR=1.110, 95%CI 1.053-1.169, P<0.001, CC+CT vs TT: OR=1.124, 95%CI 1.018-1.240, P=0.020, CC vs CT +TT: OR=1.153, 95%CI 1.071-1.241, P<0.001), suggesting that the polymorphism of rs3802177 in SLC30A8 gene is associated with the occurrence of T2DM, and the C allele is a risk gene. The results of genotype comparison showed that the most suitable genetic model was recessive model, in which individuals with CC genotypes were 1.153 times more likely to have T2DM than those with CT and TT genotypes. The results suggested SLC30A8 gene rs3802177 polymorphism is associated with type 2 diabetes in Asian population.