Abstract
BackgroundPulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonary function and the health-related quality of life (HRQL) in patients with pMAC disease.MethodsThis cross-sectional study included adult patients with pMAC and was conducted at Keio University Hospital. We investigated the relationship of 6MWT parameters with clinical parameters, including pulmonary function, and HRQL, which was assessed using the 36-Item Short Form Health Survey (SF-36) and St. George’s Respiratory Questionnaire (SGRQ).ResultsIn total, 103 consecutive patients with pMAC participated in 6MWT (median age, 64 years; 80 women) and completed SF-36 and SGRQ. The six-minute walk distance (6MWD) showed significant negative and positive correlations with all SGRQ domain scores [ρ = (− 0.54)–(− 0.32)] and the physical component summary (PCS) score (ρ = 0.39) in SF-36, respectively; the opposite was observed for the final Borg scale (FBS) score (all SGRQ scores, ρ = 0.34–0.58; PCS score, ρ = − 0.50). The distance-saturation product showed significant negative and positive correlations with all SGRQ scores [ρ = (− 0.29)–(− 0.55)] and the PCS score (ρ = 0.40), respectively. Multivariate analysis revealed that 6MWD and the FBS score were significant predictors of HRQL.ConclusionsOur findings suggest that 6MWD and the FBS score are useful parameters for evaluating HRQL in patients with pMAC. Further studies should investigate the impact of 6WMT parameters on disease progression, treatment responses, and prognosis.
Highlights
Pulmonary Mycobacterium avium complex disease is a chronic, slowly progressive disease
Comparisons of six-minute walk test (6MWT) parameters and questionnaire scores between patients with cavitary lesions and those without We evaluated whether 6MWT parameters and the questionnaire scores differed between patients with cavitary lesions (n = 31, 30.1%) on High-resolution computed tomography (HRCT) and those without (n = 72, 69.9%; Additional file 1: Table S6), because cavitary lesions have been reported as a prognostic factor for Pulmonary Mycobacterium avium complex (pMAC) disease [22, 23]
In the present study, we evaluated the relationship of 6MWT parameters with clinical parameters, including pulmonary function test (PFT) findings, and health-related quality of life (HRQL) in patients with pMAC disease
Summary
Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonary function and the health-related quality of life (HRQL) in patients with pMAC disease. Pulmonary Mycobacterium avium complex (pMAC) disease, the most common form of NTM infection, presents as a chronic, slowly progressive disease in immunocompetent patients [3]. It causes chronic pulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD) and is generally incurable, requires long-term antimicrobial therapy, and has a high recurrence rate after treatment discontinuation [3]. The correlations between HRQL and various 6MWT parameters remain unknown
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