Abstract
BackgroundTo investigate whether the mitochondrial transcription factor A (TFAM) rs1937 single nucleotide polymorphism (SNP) is associated with longevity.MethodsWe conducted a case-control study among Chinese long-lived individuals (≥90 years). Data were obtained on 3294 participants who were able to voluntarily provided a saliva sample during 2008–2009 from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). In this study, 1387 young elderly (65–74 years) were allocated to the control group, and 1907 long-lived individuals were recruited as the case group. SNP rs1937 on TFAM were genotyped. Logistic regression models were applied to evaluate the association between rs1937 SNP and longevity.ResultsThe genotype frequency of the SNP of rs1937 in the two groups had a significant difference (p = 0.003). Binary logistic regression analysis showed that compared to younger elderly, the long-lived individuals with “CC genotype” of rs1937 were more closely related to increased longevity than those with “GG genotype” (OR: 1.989, 95% CI: 1.160–3.411). The positive association between rs1937 SNP and longevity was robust in stratified analyses and sensitivity analyses.ConclusionsWe found the SNP of rs1937 may be a potential biomarker for longer human life span. Further studies are necessary to elucidate the biological mechanism of rs1937 on TFAM with promoting longevity.
Highlights
To investigate whether the mitochondrial transcription factor A (TFAM) rs1937 single nucleotide poly‐ morphism (SNP) is associated with longevity
Of the 3294 participants, 1907 nonagenarians and centenarians were enrolled in the long-lived individuals group, of which 701 (36.8%) were men; 1387 young old were enrolled in the younger elderly group, of which 766 (55.2%) were men
Interquartile range (IQR) interquartile range a Literacy was defined as receiving a formal education of more than one year, illiteracy was defined as receiving a formal education of less than one year
Summary
To investigate whether the mitochondrial transcription factor A (TFAM) rs1937 single nucleotide poly‐ morphism (SNP) is associated with longevity. Mitochondria are one of the most important and intense studied organelles involved in cellular senescence and organismal aging [1], and they contain mitochondrial DNA (mtDNA) of the extranuclear genome. Several population-based studies [13, 19,20,21] have suggested that the single nucleotide polymorphism (SNP) of rs1937 on TFAM were associated with Alzheimer’s disease (AD). A recent study investigated TFAM deficiency could induce multimorbidity and premature senescence mediating by T cells with dysfunctional mitochondria [22]. Relatively little is known about the associations between SNPs rs1937 and human longevity, in the Chinese long-living individuals
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