Association between short-term exposure to ambient particulate air pollution and biomarkers of oxidative stress: A meta-analysis

Abstract

BackgroundExposure to ambient particulate air pollution contributes substantially to the mortality and morbidity due to cardiovascular diseases (CVD), respiratory diseases and neurodegenerative diseases. Several hypothetical mechanisms have been proposed to explain these associations, particularly oxidative stress. Malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and Superoxide Dismutase (SOD) are typical biomarkers of oxidative stress and have been frequently investigated. However, the association between exposure to ambient particulate matter (PM) and these biomarkers has not been well established. ObjectivesEvaluate the association between ambient particulate air pollution and biomarkers of oxidative stress based on existing epidemiological studies. MethodsA systematic literature search was conducted in databases of Science Direct, PubMed, Web of Science, and Scopus up to April 24, 2020 to summarize epidemiological studies reporting the association between exposure to ambient PM (PM2.5, PM10, or both) and biomarkers of oxidative stress, and a meta-analysis was performed for the associations reported in individual studies using a random-effect model. ResultsThis meta-analysis included 23 epidemiological studies (13 identified for 8-OHdG, 11 identified for MDA and 5 identified for SOD). A 10 μg/m3 increase in short-term exposure to ambient PM2.5 was associated with pooled percent changes of 2.10% (95% CIs: −0.13%, 4.38%), 1.60% (95% CIs: 0.21%, 3.01%) and −0.61% (95% CIs: −1.92%, 0.72%) in 8-OHdG, MDA and SOD, respectively. ConclusionShort-term exposure to ambient PM2.5 was associated with a significantly increased level of MDA, indicating that ambient particulate air pollution may contribute to increased oxidative stress.