Abstract
BackgroundUric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D is still unclear in the eastern Chinese population.MethodsWe did a population-based observational investigation, which included 12,770 residents living in eastern China. Ultimately, data from 9220 subjects were analyzed. Serum 25(OH) D, SUA, fasting plasma glucose (FPG), fasting insulin, HbA1c and other metabolic parameters were tested. Waist circumference (WC), weight and height were also measured. Questionnaires were collected from these subjects for information on smoking and drinking status.ResultsWe enrolled 9220 Chinese adults, including 3681 males (age 55.57 ± 13.23 years) and 5539 females (age 54.31 ± 12.83 years). The levels of SUA were 352.07 ± 79.25 nmol/L and 269.29 ± 64.68 nmol/L in males and females, respectively. The proportion of adults with hyperuricemia (HUA) was 12.26% in the total population. Levels of SUA were positively associated with 25(OH) D, and the incidence of HUA increased 9.4% for every 10 nmol/L increase in 25(OH) D (P < 0.001).ConclusionsSUA was positively associated with 25(OH) D in the eastern Chinese population. Higher levels of serum 25(OH) D may be a potential predictor of HUA.
Highlights
Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome
Vitamin D is generally regarded as an important prohormone, that can participate in regulating the metabolism of calcium phosphate and bone physiology
Indexes comparison between different groups In our study, we analyzed the association of 25(OH) D with UA in 9220 Chinese adults, including 3681 males and 5539 females
Summary
Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. Vitamin D is an essential fat-soluble vitamin for humans. It can be produced in the skin when the epidermis is exposed to ultraviolet B radiation or it can be obtained from the diet, including ergocalciferol (D2) from plants and cholecalciferol (D3) mostly from marine life. The primary source of vitamin D is the keratinocytes of the skin [1]. Vitamin D is activated by hydroxylases, namely, Vitamin D is generally regarded as an important prohormone, that can participate in regulating the metabolism of calcium phosphate and bone physiology. An increasing number of studies have shown that vitamin D is involved in many other diseases. Through its ubiquitously expressed receptor, calcitriol displays potent anti-angiogenic and anti-inflammatory activity
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