Association between serum uric acid levels and achievement of target blood pressure among Japanese community residents with hypertension.

Abstract

The authors examined the sex-specific association between serum uric acid (SUA) levels and achievement of target blood pressure among Japanese patients with hypertension. This cross-sectional study was conducted between January 2012 and December 2015 and examined 17113 eligible participants (6499 men; 10614 women) with hypertension among 66874 Japanese community residents who underwent voluntary health checkups. Multivariate analysis was used to estimate the association between high SUA level (≥7.0mg/dL for men and ≥6.0mg/dL for women) and "therapeutic failure" in achieving target blood pressure (BP) of 140/90 and 130/80mmHg in both sexes. Multivariate analysis revealed that high SUA level was significantly associated with failure to achieve the 130/80mmHg treatment goal among men (AOR=1.24, 95% CI=1.03-1.50, p=.03). Among women, high SUA level was significantly associated with failure to achieve both the 130/80 and 140/90mmHg treatment goals (AOR=1.33, 95% CI=1.20-1.47, p<.01 and AOR=1.17, 95% CI=1.04-1.32, p<.01, respectively). Each increase in SUA quartile was positively associated with increases in systolic BP (SBP) and diastolic BP (DBP) (p<.01 for trend) in both sexes. SBP and DBP in each quartile (Q2-Q4) were also significantly higher compared with those of Q1 in both sexes (p<.01). Our data confirms the difficulties in maintain goal BP control in those with elevated SUA.