Abstract
The level of serum uric acid (SUA) has been reported to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). However, this association remains unclear in patients with chronic kidney disease (CKD). A total of 1025 patients with pre-dialysis CKD with preserved left ventricular systolic function were enrolled in this cross-sectional study. The LVH and LVDD were assessed using two-dimensional echocardiography and tissue Doppler imaging. The associations of LVH/LVDD with clinical and laboratory variables were investigated using univariable and multivariable logistic regression analyses. In a multivariable analysis, the SUA level was an independent predictor of LVH (odds ratio [OR]: 1.40, 95% confidence interval [CI]: 1.31-1.50, P < 0.001). In addition, patient age, systolic blood pressure, intact parathyroid hormone levels, and left atrial volume index levels were independent predictors of LVH. The SUA level was also an independent predictor of LVDD (OR: 1.93, 95% CI: 1.53-2.43, P < 0.001). Furthermore, systolic blood pressure and left atrial volume index levels were an independent predictor of LVDD. Receiver-operating characteristic curve analysis showed that the best cutoff values of SUA levels for identifying LVH and LVDD were ≥ 7.5 mg/dL and ≥ 6.3 mg/dL, respectively. The SUA level was an independent predictor of LVD and LVDD in patients with CKD, suggesting that SUA could be a biomarker for LVH and LVDD.
Highlights
Cardiovascular disease (CVD) is the primary cause of death in patients with chronic kidney disease (CKD) [1]
The serum uric acid (SUA) level was an independent predictor of left ventricular hypertrophy (LVH)
The SUA level was an independent predictor of LVD and left ventricular diastolic dysfunction (LVDD) in patients with CKD, suggesting that SUA could be a biomarker for LVH and LVDD
Summary
Cardiovascular disease (CVD) is the primary cause of death in patients with chronic kidney disease (CKD) [1]. Of all cardiac problems in patients with CKD, left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) are common and closely related to increased CVD mortality in these patients [2, 4]. Beyond its role in gout, previous epidemiologic studies have suggested that an increased serum uric acid (SUA) level is a risk factor for various cardiovascular conditions, including hypertension, metabolic syndrome, coronary artery disease, cerebrovascular disease, vascular dementia, and kidney disease [7]. The level of serum uric acid (SUA) has been reported to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). This association remains unclear in patients with chronic kidney disease (CKD).
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