Association between serum phospholipid fatty acid levels and adiposity in Mexican women

Elom K Aglago,Carine Biessy,Gabriela Torres-Mejía,Angélica Angeles-Llerenas,Marc J Gunter,Isabelle Romieu,Veronique Chajès

doi:10.1194/jlr.p073643

Abstract

Fatty acids (FAs) have been postulated to impact adiposity, but few epidemiological studies addressing this hypothesis have been conducted. This study investigated the association between serum phospholipid FAs (S-PLFAs) and indicators of obesity. BMI and waist-to-hip ratio (WHR) were collected from 372 healthy Mexican women included as controls in a case-control study. S-PLFA percentages were determined through gas chromatography. Desaturation indices, SCD-16, SCD-18, FA desaturase (FADS)1, and FADS2, biomarkers of endogenous metabolism, were proxied respectively as 16:1n-7/16:0, 18:1n-9/18:0, 20:4n-6/20:3n-6, and 22:6n-3/20:5n-3. Multiple linear regressions adjusted for relevant confounders and corrected for multiple testing were conducted to determine the association between S-PLFA, desaturation indices, and indicators of adiposity. SCD-16 (β = 0.034, P = 0.001, q = 0.014), palmitoleic acid (β = 0.031, P = 0.001, q = 0.014), and dihomo-γ-linolenic acid (β = 0.043, P = 0.000, q = 0.0002) were positively associated with BMI. Total n-6 PUFAs (β = 1.497, P = 0.047, q = 0.22) and the ratio of n-6/n-3 PUFAs (β = 0.034, P = 0.040, q = 0.19) were positively associated with WHR, while odd-chain FAs (pentadecanoic and heptadecanoic acid) showed negative associations with all the adiposity indicators. In conclusion, increased endogenous synthesis of palmitoleic acid and a high n-6/n-3 ratio are associated with increased adiposity, while odd-chain FAs are associated with decreased adiposity. Further studies are needed to determine the potential causality behind these associations.

Highlights

Fatty acids (FAs) have been postulated to impact adiposity, but few epidemiological studies addressing this hypothesis have been conducted
The associations remained significant and positive for SCD-16 and negative for FADS1 after adjustment for multiple testing. This is the first epidemiologic study to report the association between serum (or plasma) phospholipid FA (S-PLFA) levels and the indicators of obesity in a population of Mexican women
We found that desaturation index, SCD-16, as a marker of endogenous synthesis of monounsaturated palmitoleic acid, was positively associated with BMI and waist circumference

Summary

Introduction

Fatty acids (FAs) have been postulated to impact adiposity, but few epidemiological studies addressing this hypothesis have been conducted. This study investigated the association between serum phospholipid FAs (S-PLFAs) and indicators of obesity. Total n-6 PUFAs ( = 1.497, P = 0.047, q = 0.22) and the ratio of n-6/n-3 PUFAs ( = 0.034, P = 0.040, q = 0.19) were positively associated with WHR, while odd-chain FAs (pentadecanoic and heptadecanoic acid) showed negative associations with all the adiposity indicators. Increased endogenous synthesis of palmitoleic acid and a high n-6/n-3 ratio are associated with increased adiposity, while odd-chain FAs are associated with decreased adiposity. Association between serum phospholipid fatty acid levels and adiposity in Mexican women. Approximately 65.3% of Mexican women are overweight or obese [1]. Astrup, and Donahoo [6] summarized interventional prospective cohorts and cross-sectional studies and reported mitigated associations, increased intakes of saturated FAs (SFAs), MUFAs, and trans FAs (TFAs) were associated with slightly higher risk of obesity, while a minor protective effect was reported for PUFAs

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