Association between Serum PBDE Levels and Residential Proximity to Solid Waste Facilities/Landfills or Toxics Release Facilities

Abstract

Association between Serum PBDE Levels and Residential Proximity to Solid Waste Facilities/Landfills or Toxics Release FacilitiesAbstract Number:2054 Ruiling Liu*, David Nelson, Susan Hurley, Myrto Petreas, Yunzhu Wang, Tan Guo, June-Soo Park, Pamela Horn-Ross, Leslie Bernstein, Hoda Anton-Culver, Andrew Hertz, and Peggy Reynolds Ruiling Liu* Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , David Nelson Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , Susan Hurley Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , Myrto Petreas California Department of Toxic Substances Control, United States, E-mail Address: [email protected] Search for more papers by this author , Yunzhu Wang Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , Tan Guo Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , June-Soo Park Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , Pamela Horn-Ross Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , Leslie Bernstein Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , Hoda Anton-Culver Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , Andrew Hertz Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author , and Peggy Reynolds Cancer Prevention Institute of California, United States, E-mail Address: [email protected] Search for more papers by this author AbstractINTRODUCTION Some studies have examined the relationship between characteristics of indoor environments and human polybrominated diphenyl ether (PBDE) body burden, but relatively few have considered the role of outdoor environments as potential exposure sources. AIM We examined the association between serum PBDE levels in California women and residential proximity to solid waste facilities/landfills or toxics release facilities, which may release PBDEs into the environment.METHODS Blood samples, collected in 2011-2013 from 481 participants (median age=66 years; range 40-94 years) in the California Teachers Study, were assayed for 19 PBDE congeners via Gas Chromatography/High Resolution Mass Spectrometry. Information on solid waste facilities/landfills was obtained from the California Solid Waste Information System, and for toxics release facilities from the U.S. Environmental Protection Agency Toxics Release Inventory program. Facilities with potential for release of flame-retardants were identified and geocoded, and the distance to each participant’s residential address at time of blood draw was computed. Linear regression was used to examine the association between the proximity to those facilities and the serum levels of the three most common PBDE congeners (BDE-47, -100 and -153), adjusting for age, race, body mass index and neighborhood (block group) socioeconomic status. Serum PBDE levels were lipid adjusted (ng/g lipid) and log-transformed for analysis.RESULTS Preliminary results indicate that participants living within 10km of any solid waste facility/landfill may have higher serum BDE-47 levels than those living beyond 10km. No associations were observed for BDE-100 or -153, or for proximity to toxics release facilities.CONCLUSION Living within 10km of some solid waste facilities/landfills may be related to higher serum BDE-47 levels. Further analyses are needed to examine the dose response relationships and the potential roles of facility type.