Association between serum nitric oxide metabolites and thyroid hormones in a general population: Tehran Thyroid Study

Abstract

ABSTRACTNitric oxide participates in the regulation of thyroid function. Aims: The purpose of this study was to determine whether there is an association between serum nitric oxide metabolites (NOx) and free thyroxine (free T4), anti-thyroid peroxidase (anti-TPO), and thyroid-stimulating hormone (TSH) levels. Methods: Study subjects were adults, aged ≥20 years, who participated in the Tehran Thyroid Study (TTS). In a cross-sectional study, in the third phase of TTS, serum NOx concentrations were measured in 1974 adult participants; pregnant women and subjects who had chronic diarrhea, cancer, weight loss, and hospitalization within the past 3 months were excluded, as were those taking medicines that affect thyroid function; the remaining 1771 subjects were grouped according to tertiles of free T4, anti-TPO, and TSH. Spearman’s correlation coefficients and multivariable linear regression analysis were used to determine the relationship between serum NOx levels and free T4, anti-TPO, and TSH. Results: Serum NOx levels were negatively correlated with free T4 in men (r = −0.083; p = 0.029). An inverse association between the third tertile of free T4 and NOx levels was found in both non-adjusted (β = −0.095, p = 0.031) and multivariable-adjusted (β = −0.094, p = 0.039) analyses, only in men. After multivariable adjustment, the third tertile of anti-TPO was significantly associated with NOx levels in women (β = −0.067, p = 0.050). Conclusions: Based on the result, serum NOx concentration was found to be associated with free T4 in men and anti-TPO in women.