Abstract
Essential hypertension is widespread and has significant morbidity and mortality. However, the genetic basis of the disease is unknown. MicroRNAs are post-transcriptional regulators and have been implicated in development of the disease. The aim of this study was to assess the relationship between serum microRNA-605 and microRNA-623 expression and essential hypertension in Egyptian patients. MicroRNA expression in serum was determined in hypertensive patients and normotensive controls by quantitative real-time polymerase chain reaction. Hypertensive patients had significantly higher expression of both microRNA-605 (11 fold increase, p < 0.001) and microRNA-623 (22 fold increase, p = 0.001) than normotensive controls. Neither microRNA-605 nor microRNA-623 expression was significantly correlated with systolic or diastolic blood pressure. MicroRNA-605 expression was positively correlated with elevated serum total cholesterol, low density lipoprotein, and was negatively correlated with serum high density lipoprotein (HDL). MicroRNA-623 expression was negatively correlated with serum HDL. Results from the study indicate that the microRNAs studied are not directly associated with presence of essential hypertension, but are associated with dyslipidemia commonly associated with the disease.
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