Association between serum insulin-like growth factor I or IGF-binding protein 3 and estimated glomerular filtration rate: results of a population-based sample

Kathleen Dittmann,Sylvia Stracke,Rainer Rettig,Henri Wallaschofski,Matthias Nauck,Nele Friedrich,Karlhans Endlich,Henry Völzke

doi:10.1186/1471-2369-13-169

Kathleen Dittmann, Sylvia Stracke + Show 6 more

Open Access

https://doi.org/10.1186/1471-2369-13-169

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Journal: BMC Nephrology	Publication Date: Dec 1, 2012
Citations: 28	License type: CC BY 2.0

Affiliation: University of Greifswald

Abstract

BackgroundInsulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study among US adults. The aim of the present study was to investigate whether serum IGF-I or IGFBP-3 are associated with estimated glomerular filtration rate (eGFR) in a population-based study of Caucasian adults.MethodsData from 4028 subjects (2048 women) aged 20 to 81 years from the Study of Health in Pomerania (SHIP) were analyzed. Total serum IGF-I and IGFBP-3 concentrations were determined by chemiluminescence immunoassays and categorized into sex- and age-specific quartiles.ResultsAfter adjusting for age, waist circumference and type 2 diabetes mellitus, analysis of variance (ANOVA) revealed inverse associations between serum IGF-I concentrations and eGFR in men as well as between serum IGFBP-3 concentrations and eGFR in men and women. Logistic regression analyses confirmed these findings and showed that high IGF-I or IGFBP-3 concentrations were associated with an increased risk of decreased eGFR (<60 mL/min/1.73 m2) in men or women. These relations became stronger when lower eGFR cut-offs were used for the analyses.ConclusionOur data revealed associations of increased serum IGF-I concentrations and decreased eGFR in men but not in women and an association of increased serum IGFBP-3 concentrations and decreased eGFR in both sexes.

Highlights

Insulin-like growth factor I (IGF-I), which is mostly carried in blood by insulin-like growth factor (IGF)-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study among US adults
To clarify the association between IGF-I or IGF-binding protein 3 (IGFBP-3) and renal dysfunction we used logistic regression models adjusted for age, waist circumference and type 2 diabetes mellitus
Using serum IGF-I or IGF-binding proteins (IGFBPs)-3 concentrations as continuous variables, we observed non-significant associations between increasing concentrations of IGF-I (men: odds ratios (ORs) for one standard deviation (SD) increase 1.2 [95% Confidence interval (CI) 0.95-1.50]; women: OR 0.97 [95% CI 0.80-1.19]) or IGFBP-3 and chronic kidney disease (CKD) (Figure 2)

Summary

Introduction

Insulin-like growth factor I (IGF-I), which is mostly carried in blood by IGF-binding protein 3 (IGFBP-3), was associated to the glomerular filtration rate and chronic kidney disease in a multiethnic study among US adults. The aim of the present study was to investigate whether serum IGF-I or IGFBP-3 are associated with estimated glomerular filtration rate (eGFR) in a population-based study of Caucasian adults. IGF-I promotes kidney growth and increases glomerular filtration rate (GFR) as well as renal plasma flow [2]. Serum IGF-I concentrations are associated with arterial hypertension [4,5] and diabetes mellitus [5], which in turn are known risk factors for chronic kidney disease (CKD). With an estimated prevalence of 11%, CKD represents a worldwide public health problem [4,5], which is associated with a poor quality of life [6] and due to renal transplantation and haemodialysis, with intensive costs [7]

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