Abstract
High serum free fatty acid (FFA) levels are associated with metabolic syndrome (MS). This study aimed to assess the association of fasting serum FFAs with nonalcoholic fatty liver disease (NAFLD) in a Chinese population. A total of 840 subjects fulfilled the diagnostic criteria of NAFLD and 331 healthy control participants were enrolled in this cross-sectional study. Fasting serum FFA levels and other clinical and laboratory parameters were measured. NAFLD patients had significantly higher serum FFA levels than controls (P < 0.001). Serum FFA levels were significantly and positively correlated with parameters of MS, inflammation indexes, and markers of hepatocellular damage. Elevated serum FFA levels were found in NAFLD subjects with individual components of MS (obesity, hypertriglyceridaemia, and hyperglycaemia). Stepwise regression showed that serum FFA levels were an independent factor predicting advanced fibrosis (FIB-4 ≥ 1.3) in NAFLD patients. Serum FFA levels correlated with NAFLD and could be used as an indicator for predicting advanced fibrosis in NAFLD patients.
Highlights
High serum free fatty acid (FFA) levels are associated with metabolic syndrome (MS)
We found that patients with nonalcoholic fatty liver disease (NAFLD) had significant differences in terms of BMI, SBP, DBP, ALT, AST, GGT, creatine kinase (CK), TG, TC, HDL-C, low-density lipoprotein cholesterol (LDL-C), FPG, uric acid (UA), HbA1C, Hcy, Fe, SA, hsCRP, WBC, pancreatic lipase (P-LIP), AMY, HGB, PLT and red blood cell distribution width (RDW) compared with controls
We used univariate regression to analyze the odds and p-values with forward selection, and we subsequently considered FFA, age, gender, BMI, c-GT, ALT, hsCRP, and presence of diabetes within the Discussion This is one of the few studies performed to date addressing changes in blood biochemical parameters in a large cohort (n 5 840) of subjects of the same ethnicity (Chinese) with NAFLD
Summary
High serum free fatty acid (FFA) levels are associated with metabolic syndrome (MS). This study aimed to assess the association of fasting serum FFAs with nonalcoholic fatty liver disease (NAFLD) in a Chinese population. Stepwise regression showed that serum FFA levels were an independent factor predicting advanced fibrosis (FIB-4 $ 1.3) in NAFLD patients. Serum FFA levels correlated with NAFLD and could be used as an indicator for predicting advanced fibrosis in NAFLD patients. Over the past two decades, a striking increase in the prevalence of MS worldwide has taken place along with the global epidemic of obesity[12] This constellation of metabolic abnormalities is becoming increasingly common in China, as shown by emerging prevalence data[13].
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