Abstract
Hyperuricemia has been recognized as a worldwide public health concern. This study was conducted to examine the association between serum copper (Cu) concentration and the prevalence of hyperuricemia in a middle-aged and elderly population. Serum Cu concentration was measured by Roche modular P800 using the PAESA method. Serum uric acid (UA) concentration was detected by a Beckman Coulter AU 5800. Presence of hyperuricemia was defined as serum UA ≥ 416 μmol/L for men and ≥360 μmol/L for women. The association between serum Cu concentration and the prevalence of hyperuricemia was evaluated by logistic regression. The prevalence of hyperuricemia was 17.6% (n = 6,212) in the present study. Relative to the lowest quintile, the age- and sex-adjusted odds ratios for hyperuricemia were 1.38 (95% CI: 1.12 to 1.70), 1.34 (95% CI: 1.07 to 1.66), and 1.53 (95% CI: 1.23 to 1.91) in the third, fourth, and fifth serum Cu concentration quintiles (P for trend < 0.001). Similar results were found both in men and women subgroups. None of the findings were materially altered after adjustment for additional potential confounders. In conclusion, in this population-based cross-sectional study, serum Cu concentration was positively associated with the prevalence of hyperuricemia.
Highlights
Hyperuricemia has been recognized as a worldwide public health concern
We modelled continuous serum Cu concentrations, estimating the effect on hyperuricemia prevalence per 10 μmol/L increase
The present cross-sectional study showed a positive association between serum Cu concentrations and the prevalence of hyperuricemia, and the findings remained consistent after adjustment for confounders
Summary
This study was conducted to examine the association between serum copper (Cu) concentration and the prevalence of hyperuricemia in a middle-aged and elderly population. The association between serum Cu concentration and the prevalence of hyperuricemia was evaluated by logistic regression. None of the findings were materially altered after adjustment for additional potential confounders In this population-based cross-sectional study, serum Cu concentration was positively associated with the prevalence of hyperuricemia. There has been no research directly related serum Cu to prevalence of hyperuricemia To fill in this knowledge gap, we used data collected from a large population-based cross-sectional study to investigate whether there is an association between serum Cu levels and the prevalence of hyperuricemia
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