Association between serum bone morphogenetic protein-2 level and in-stent restenosis after drug-eluting stent implantation

Abstract

Objective To investigate the relationship between serum bone morphogenetic protein-2(BMP-2)level and in-stent restenosis(ISR)after drug-eluting stent implantation. Methods From June of 2014 to March of 2016, a total of 324 patients with coronary artery disease who underwent drug-eluting stenting were enrolled.These patients were divided into ISR(n=54)and non-ISR(n=270)groups according to the results of coronary angiography after nearly 1 year follow up.The clinical data of the 2 groups were retrospectively compared, and the level of BMP-2 on the next morning after admission was measured by ELISA method. Results The levels of serum BMP-2 was (31.5±7.8)pg/ml and (23.1±6.0)pg/ml in the ISR and non-ISR groups respectively, with significant difference between groups(t=8.90, P<0.01). Multivariate logistic regression analysis indicated that serum BMP-2 level was an independent predictors for ISR after implantation of drug-eluting stents(OR=1.70, 95%CI: 1.16-2.48, P<0.01). The ROC curve analysis showed that the area under the curve of BMP-2 to predict ISR was 0.80(95%CI: 0.73-0.86), with a cutoff value of 26.3 pg/ml showing a sensitivity of 66% and specificity of 82%. Conclusions Serum levels of BMP-2 are closely associated with ISR after drug-eluting stents implantation, and are independent predictors for ISR. Key words: Bone morphogenetic protein 2; Coronary artery disease; Drug-eluting stents; In-stent restenosis