Abstract
BackgroundAdipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circulating A-FABP level with severity of myocardial perfusion abnormalities analyzed by Tl-201 dipyridamole single-photon emission computed tomography.MethodsA total of 170 patients with coronary artery disease (CAD) from cardiovascular clinics were enrolled in the study. Serum A-FABP levels, echocardiography, and stress myocardial perfusion imaging results were analyzed.ResultsCompared with the patients with mild CAD (summed stress score [SSS] ≤ 8), those with moderate to severe CAD (SSS > 8) had significantly higher A-FABP concentrations. However, the difference was attenuated in the subgroup of patients with heart failure. In the correlation analyses, A-FABP level was correlated with age, body mass index, waist circumference, levels of creatinine, fasting glucose, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, adiponectin, and several echocardiographic parameters, including left ventricular ejection fraction. Multivariate logistic regression analysis demonstrated that the A-FABP level was not only associated with higher SSS (odds ratio, 1.30; 95% confidence interval [CI], 1.01–1.69; P = 0.048), but also an independent risk factor for heart failure (odds ratio 2.71, 95% CI, 1.23–5.94; P = 0.013).ConclusionsSerum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD.
Highlights
Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis
Insulin resistance is closely associated with cardiovascular disease and heart failure (HF), and dysregulated adipokines, which are mainly released from adipose tissues, suggesting possible links between these conditions [1,2]
Our study demonstrated that serum A-FABP levels were associated with coronary artery disease (CAD) severity, as determined by single-photon emission computed tomography (SPECT)
Summary
Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. We investigated the association of circulating A-FABP level with severity of myocardial perfusion abnormalities analyzed by Tl-201 dipyridamole single-photon emission computed tomography. Insulin resistance is closely associated with cardiovascular disease and heart failure (HF), and dysregulated adipokines, which are mainly released from adipose tissues, suggesting possible links between these conditions [1,2]. These adipokines, including adiponectin, resistin, and leptin, are known to mediate important and cardiovascular disease. Tl-201 dipyridamole single-photon emission computed tomography (SPECT) is currently the standard tool in clinical CAD evaluation and demonstrates the extent of myocardial scar and ischemic burden. The aim of our study was to evaluate the correlation of circulating A-FABP levels with SPECT results, left ventricular function, and HF in CAD patients
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