Abstract
Aims/IntroductionTo investigate the association between serum 25‐hydroxyvitamin D (25‐[OH]D) concentrations and metabolic syndrome (MetS) in the middle‐aged and elderly Chinese population.MethodsThe present study included 2,764 participants (aged >50 years). The joint interim statement was used for the standard definition of MetS. Serum 25‐(OH)D concentrations were measured by electrochemiluminescence immunoassay. The study participants were categorized into quartiles based on serum 25‐(OH)D concentrations, and the quartiles were calculated for the differences using anova and the χ2‐test for continuous and categorical data, respectively. A logistic regression analysis model was applied to estimate the odds ratios and 95% confidence intervals (95% CI) for each quartile of serum 25‐(OH)D concentrations compared with the highest quartile.ResultsSerum 25‐(OH)D levels were markedly lower in men in the MetS group than in those without MetS. We observed a negative correlation between the higher quartiles of serum 25‐(OH)D levels and the presence of MetS among men. The correlation between serum 25‐(OH)D levels and the prevalence of MetS persisted even after adjusting for potential confounders, including age, cigarette smoking status, alcohol consumption, physical activity, low‐density lipoprotein, creatinine and total serum cholesterol. Adjusted odds ratios of MetS in the second through fourth compared with the lowest quartile for serum 25‐(OH)D levels were 0.93 (95% CI 0.54–1.59), 0.89 (95% CI 0.50–1.56) and 0.48 (95% CI 0.28–0.84), respectively.ConclusionsDecreased serum 25‐(OH)D level is significantly correlated with MetS in middle‐aged men.
Highlights
Metabolic syndrome (MetS) is a configuration of vascular risk factors, correlated with chronic conditions, such as type 2 diabetes mellitus and cardiovascular disease[1]
A recent report showed that vitamin D deficiency reduces the intracellular calcium levels and thereby depletes insulin secretion level by b-cells, which further impairs glucose tolerance[7]
We investigated the association between serum 25-(OH)D levels and the prevalence of MetS in the middle-aged and elderly population of northeast China
Summary
Metabolic syndrome (MetS) is a configuration of vascular risk factors, correlated with chronic conditions, such as type 2 diabetes mellitus and cardiovascular disease[1]. The prevalence of adults with MetS has increased globally by 25%2, and it is well established that the availability of MetS contributes to a greater risk of developing cardiovascular disease[3,4], suggesting that MetS is strongly linked with many non-communicable diseases and it is continuously increasing the prevalence of such. A recent report showed that vitamin D deficiency reduces the intracellular calcium levels and thereby depletes insulin secretion level by b-cells, which further impairs glucose tolerance[7]. Another study highlighted that vitamin D plays an essential role in glucose metabolism and insulin response by stimulating insulin receptors[8].
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