Association between Selected Polymorphisms rs12086634, rs846910, rs4844880, rs3753519 of 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD11B1) and the Presence of Insulin Resistance in the Polish Population of People Living in Upper Silesia.

Nikola Szweda-Gandor,Władysław Grzeszczak,Mirosław Śnit

doi:10.3390/ijerph181910168

Nikola Szweda-Gandor, Władysław Grzeszczak + Show 1 more

Open Access

https://doi.org/10.3390/ijerph181910168

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Abstract

Background: Many factors influence the development of insulin resistance, among other genetic factors. Cortisol is one of the factors that has a significant impact on the development of insulin resistance. The proteins that have a substantial effect on blood cortisol levels include 11β-hydroxysteroid dehydrogenase type 1. HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. Gene encoding HSD11B1 is located on 1q32.2. This study was designed to assess the association between four polymorphic sides in HSD11B1 (rs12086634, rs846910, rs4844880, rs3753519) between subjects with and without insulin resistance in the Polish population of people living in Upper Silesia. Methods: The study included a total of 507 consecutive patients, 374 (73.77%) with and 133 (26.23%) without insulin resistance. Results: The results show that there were no statistically significant differences in the distribution of genotypes and alleles of the examined polymorphisms of the 11β-hydroxysteroid dehydrogenase type 1 gene between subjects with and without insulin resistance (determined using the HOMA-IR, insulin resistance index) and that rs846910 and rs1208663 polymorphisms of the 11β-hydroxysteroid dehydrogenase type 1 gene in the examined subjects have a significant effect on the magnitude of the HOMA-IR insulin resistance index. Conclusions: The study results suggested that genetic variation of rs846910 and rs1208663 polymorphism of the HSD11B1 gene is related to the susceptibility to insulin resistance. Our results provide a basis to begin basic research on the role of the HSD11B1 gene in the pathogenesis of insulin resistance.

Highlights

Insulin resistance is a condition of decreased tissue sensitivity to insulin
In the 11β-hydroxysteroid dehydrogenase type 1 gene (HSD11B1), we examined the distribution of the following polymorphisms: HSD11B1 rs12086634, HSD11B1 rs846910, HSD11B1 rs4844880, HSD11B1 rs3753519
Our results showed that there was no statistically significant difference in the distribution of rs12086634, rs846910, rs4844880, rs3753519 genotypes of the HSD11B1 gene in subjects with and without insulin resistance

Summary

Introduction

Insulin resistance is a condition of decreased tissue sensitivity to insulin. Insulin resistance may be primary (due to inheritance of a genetic mutation) or secondary [1,2,3,4].Increased insulin resistance increases indirectly the incidence of myocardial infarction, stroke, peripheral arteriosclerosis, and increased blood pressure [5,6,7]. Many factors influence the development of insulin resistance, including genetic factors [12,15,16]. Among the proteins that have a significant effect on blood cortisol levels, there is 11β-hydroxysteroid dehydrogenase type 1 [19]. Cortisol is one of the factors that has a significant impact on the development of insulin resistance. Results: The results show that there were no statistically significant differences in the distribution of genotypes and alleles of the examined polymorphisms of the 11β-hydroxysteroid dehydrogenase type 1 gene between subjects with and without insulin resistance (determined using the HOMA-IR, insulin resistance index) and that rs846910 and rs1208663 polymorphisms of the

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