Abstract
BackgroundA recent meta-analysis found that secreted phosphoprotein-1 (SPP1) can predict the risk of both osteoporosis and fracture. No study has explored the association of SPP1 haplotype-tagging single nucleotide polymorphisms (htSNPs) and haplotypes with bone mineral density (BMD).MethodsThis is a cross-sectional study. A total of 1,313 healthy Taiwanese women aged 40 to 55 years were recruited from MJ Health Management Institute from 2009 to 2010. BMD was dichotomized into high and low BMD groups. Three common (allele frequency ≥5%) htSNPs were selected to examine the association between sequence variants of SPP1 and BMD.ResultsHomozygosity for the T allele of rs4754 were protective from low BMD [TT vs. CC: adjusted OR (AOR) = 0.58, 95% confidence interval (CI) = 0.83–0.89]. A protective effect was also found for women carrying 2 copies of Hap3 TCT (AOR = 0.57, 95% CI = 0.34–0.95). Menopausal status marginally interacted with SPP1 rs6839524 on BMD (p = 0.049). Postmenopausal women carrying variant rs6839524 (GG+GC vs. CC: AOR = 2.35, 95% CI = 1.06–5.20) or Hap1 TGC (AOR = 2.36, 95% CI = 1.06–5.24) were associated with 2.4-fold risk of low BMD. For women with low BMI (<18.5 kg/m2), variant rs6839524 (AOR = 7.64) and Hap1 (AOR = 6.42) were associated with increased risk of low BMD. These findings did not reach statistical significance after correction for multiple tests.Conclusions SPP1 htSNP protected against low BMD in middle-aged women. SPP1 genetic markers may be important for the prediction of osteoporosis at an early age.
Highlights
Osteoporosis, characterized by low bone mass and propensity to fracture, has become a global health issue as the rapid growth of aging population [1,2]
We evaluated the interactions between secreted phosphoprotein-1 (SPP1) polymorphisms and menopausal status or body mass index (BMI) on bone mineral density (BMD), which has not been explored previously
The minor allele frequencies (MAFs) of these single nucleotide polymorphism (SNP) ranged from 31% to 42%, which were similar to the MAFs of CHB data from International HapMap Project (29 to 38%)
Summary
Osteoporosis, characterized by low bone mass and propensity to fracture, has become a global health issue as the rapid growth of aging population [1,2]. In the US (1988–1994), the prevalence of osteoporosis was highest among white (19%), followed by Mexican American (16%) and black (7%) [4], which in part correspondence to the levels of bone mineral density (BMD) ranged from lowest in Asian, followed by native Americans, Hispanic, and African American [5]. This may be explained by different lifestyle in the East and West. No study has explored the association of SPP1 haplotype-tagging single nucleotide polymorphisms (htSNPs) and haplotypes with bone mineral density (BMD)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
