Abstract
Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and secondary thrombocytosis were analyzed retrospectively. The blood platelet count and the presence of respiratory viruses were determined for 3156 RTI patients, and 817 (25.9%) cases with platelet ≥500 × 109/L were considered as the thrombocytosis group. Compared with the normal group, the detection rates of respiratory syncytial virus (RSV) and human rhinovirus (HRV) were significantly higher in the thrombocytosis group (P = 0.017 and 0.042, respectively). HRV single infection was a risk factor associated with thrombocytosis [odds ratio (OR) = 1.560, 95% confidence interval (CI) = 1.108–2.197]. Furthermore, ST was more likely to occur in younger patients who had clinical manifestations of wheezing and dyspnea and who had been diagnosed with bronchiolitis. Furthermore, the course of disease lasted longer in these patients. ST is associated with viral respiratory tract infections, especially RSV and HRV infections. HRV single infection is a risk factor associated with thrombocytosis.
Highlights
657 (80.4%) with counts between 500 and 699 × 109/L were considered as having mild thrombocytosis, and 160 (19.6%) patients with counts of ≥ 700 × 109/L were classified as having moderate to severe thrombocytosis; this last group included 10 patients with platelet counts > 1000 × 109/L
ST is primarily found in pediatric patients with respiratory tract infections
ST was identified in approximately 25.9% (817) of the 3156 inpatients with respiratory tract infections (RTIs)
Summary
The aim of our present study was to determine the relationship between viral respiratory tract infections and ST in hospitalized children with respiratory tract infections
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