Abstract
We report here novel Schiff bases of 5-substituted-1H Indole-2, 3 Dione comparing modified with aromatic primary amine and hydrazine. A recombinant with Mannich base has been synthesized. A structure of the synthesized compounds was analyzed for structure confirmed by mass spectral data. Compound 1a-p has screened for anti-convulsant activity, increased in latency time and reduction in duration of convulsion and standard drug when compared, sodium valporate 300mg/kg. PTZ dose of 90mg/kg produced severe clonic convulsions in 88% of the mice injected, with a mean onset time of 3.61 ± 0.5 min and 80% mortality. Clonic convulsive activity lasted 2.3±0.45 min and has postictal period of decreased motor activity and subsequently. Test result revealed that compounds at dose of 300 mg/kg, the severity and duration of the convulsive episode following PTZ has not observed.
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