Abstract
We assessed the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Kawasaki disease (KD)-like multisystem inflammatory syndrome in a retrospective case–control study in France. RT-PCR and serological tests revealed SARS-CoV-2 infection in 17/23 cases vs 11/102 controls (matched odds ratio: 26.4; 95% confidence interval: 6.0–116.9), indicating strong association between SARS-CoV-2 infection and KD-like illness. Clinicians should keep a high level of suspicion for KD-like illness during the COVID-19 pandemic.
Highlights
We assessed the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Kawasaki disease (KD)-like multisystem inflammatory syndrome in a retrospective case– control study in France
Clinicians should keep a high level of suspicion for KD-like illness during the COVID-19 pandemic
We described baseline characteristics of cases and controls and performed conditional logistic regressions to calculate matched odds ratios (ORs) to assess the association between SARS-CoV-2 infection and KD-like illness
Summary
The study protocol was approved by the Necker Hospital Institutional Review Board (No 20200618174239) and by an ethical committee (CPP Ouest IV, No DC-2017–2987). Among 30 eligible cases (i.e. all cases with KD-like illness hospitalised in our general paediatric department) and 605 controls already described elsewhere [3,6], the matching process could not identify controls for seven cases; these were excluded from the case–control study. Analyses relied on data for 23 cases with KD-like illness (mean age 6.8; range: 0.3–16.6 years) and 102 controls (mean age 5.8; range: 0.05–16.0 years), slightly less than half of whom were females (Figure and Table). 17 of 23 (74%) cases and 11 of 102 (11%) controls tested positive for SARS-CoV-2 by RT-PCR and/ or serology (matched OR: 26.4; 95% confidence interval (CI): 6.0–116.9). The association remained significant when limiting the assessment to RT-PCR results and serological results separately (matched OR: 13.9; 95% CI: 2.8–68.6 and 27.7; 95% CI: 6.3–122.7, respectively; Table). CI: confidence interval; NA: not applicable; OR: odds ratio; RT-PCR: reverse transcription-PCR; SD: standard deviation. a Conditional logistic regression with patients matched on ZIP code and age
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
