Association between rs7517847 and rs2201841 polymorphisms in IL-23 receptor gene and risk of ankylosing spondylitis: a meta-analysis.

Bin Xu,Jian-Xiong Ma,Rui Feng,Li-Yan Xu,Xin-Long Ma,Hao-Bo Jia

doi:10.7717/peerj.910

Abstract

To comprehensively evaluate the association between rs7517847 and rs2201841 polymorphisms in the Interleukin-23 (IL-23) receptor gene and ankylosing spondylitis (AS), a meta-analysis was performed. The Pubmed, Embase, MEDLINE, Cochrane, China National Knowledge Infrastructure (CNKI), VIP, Wanfang and China Biology Medicine disc (CBMdisc) databases were searched to identify eligible studies on rs7517847 and rs2201841 polymorphisms in the IL-23 receptor gene and AS that were published through September 2014. Data of interest were extracted from each study, and the meta-analysis was performed using STATA 12.0. Four studies were eligible for the meta-analysis and included a total patient population of 2,465. With regards to rs7517847, the current study showed that the genotype GG and allele G might play a protective role during AS (OR = 0.76, 95% CI [0.59–0.99]; OR = 0.88, 95% CI [0.78–0.99] for homozygote and allelic models, respectively). However, according to the meta-analysis, there was no statistical association between the genotype or allele of rs2201841 and an individual’s susceptibility to AS in all genetic models. In conclusion, it was the IL-23 rs7517847 polymorphism rather than the rs2201841 polymorphism that had a statistical association with AS. Nevertheless, more evidence is needed to confirm this result. Consequently, it is necessary to carry out more high-quality studies to confirm the associations between these two single nucleotide polymorphisms and AS.

Highlights

Ankylosing spondylitis (AS) is an autoimmune disease that features chronic inflammation and ossification of the sacroiliac articulation and enthesis of the tendon
This study provides more comprehensive evidence for rheumatologists considering the association between interleukin-23 receptor (IL-23R) single nucleotide polymorphisms (SNPs) and AS
420 trials were excluded for the following reasons: (1) 116 were duplicate articles; (2) 281 did not discuss the association between IL-23R SNPs and AS in the title and abstract; (3) 20 did not discuss the association between rs7517847 and rs2201841 and AS in the full-text; (4) two contained genotype distribution data that were not publicly available, and email contact with the main authors could not be achieved; and (5) two studies assessed overlapping populations (Safrany et al, 2009; Szabo et al, 2013)

Summary

Introduction

Ankylosing spondylitis (AS) is an autoimmune disease that features chronic inflammation and ossification of the sacroiliac articulation and enthesis of the tendon. 0.2% of the general population suffers from AS, and its incidence is 0.1–1.4%, 0.2–0.54%, 0.86%, and 2% in European, Chinese, Caucasian, and HLA-B27-positive populations, respectively (Braun & Sieper, 2007; Zeng et al, 2008; Braun et al, 1998; Goldman & Schafer, 2012). How to cite this article Xu et al (2015), Association between rs7517847 and rs2201841 polymorphisms in IL-23 receptor gene and risk of ankylosing spondylitis: a meta-analysis. Wang et al (2010) found that there was a significantly higher mRNA expression of the interleukin-23 receptor (IL-23R) gene in peripheral blood monocytes of AS patients compared with those of normal controls. In accordance with a genome-wide association study (GWAS), it was shown that there was an association between IL-23R and AS in Caucasian patients (Burton et al, 2007)

Methods

Results

Discussion

Conclusion